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冷凝制丸機

冷凝制丸機指(zhi)固體或(huo)(huo)液體藥物(wu)與適(shi)宜的(de)基質加(jia)熱熔融后(hou)溶解、乳化或(huo)(huo)混懸于基質中(zhong)(zhong)后(hou)，再滴(di)入(ru)不相(xiang)混溶、互不作(zuo)用(yong)的(de)冷凝液中(zhong)(zhong)，由(you)于表(biao)面張力的(de)作(zuo)用(yong)使液滴(di)收縮成球狀而制(zhi)成的(de)一種制(zhi)劑(ji)(ji)(ji)。由(you)于滴(di)丸(wan)劑(ji)(ji)(ji)具(ju)有(you)現(xian)代(dai)藥物(wu)制(zhi)劑(ji)(ji)(ji)的(de)“三小"（用(yong)量小、毒性小、副作(zuo)用(yong)小），“三效"（高效、長效、*）和方(fang)便用(yong)藥、方(fang)便攜帶、方(fang)便貯存等(deng)諸多優點，因而廣泛應用(yong)于臨床。中(zhong)(zhong)藥滴(di)丸(wan)劑(ji)(ji)(ji)是在中(zhong)(zhong)藥丸(wan)劑(ji)(ji)(ji)基礎(chu)上發(fa)展起來(lai)的(de)，具(ju)有(you)傳統丸(wan)劑(ji)(ji)(ji)所(suo)沒有(you)的(de)特點。

滴(di)(di)制(zhi)技術先(xian)用于(yu)化(hua)學(xue)工(gong)業，國(guo)內始于(yu)1958年。中(zhong)藥(yao)(yao)滴(di)(di)丸(wan)(wan)的(de)(de)zui早試(shi)制(zhi)是1968年重慶(qing)制(zhi)藥(yao)(yao)八廠等單位在研(yan)制(zhi)民間(jian)治療慢性(xing)氣管炎、哮喘病的(de)(de)中(zhong)草藥(yao)(yao)蕓香草油時，經過一系(xi)列劑(ji)型試(shi)制(zhi)失敗后(hou)，采(cai)用滴(di)(di)丸(wan)(wan)試(shi)制(zhi)成功(gong)， 開啟了(le)中(zhong)藥(yao)(yao)滴(di)(di)丸(wan)(wan)劑(ji)研(yan)究、生產的(de)(de)序幕。1982年*救(jiu)心丸(wan)(wan)研(yan)發成功(gong)，推(tui)動了(le)中(zhong)藥(yao)(yao)滴(di)(di)丸(wan)(wan)劑(ji)規模(mo)化(hua)生產的(de)(de)進程。中(zhong)藥(yao)(yao)滴(di)(di)丸(wan)(wan)劑(ji)于(yu)1990年開始收(shou)載(zai)入中(zhong)國(guo)藥(yao)(yao)典。

制備中藥(yao)滴(di)(di)丸(wan)(wan)(wan)時(shi)，除(chu)主藥(yao)外(wai)其基質和冷凝劑的選(xuan)擇關系(xi)到產品的成敗。常(chang)(chang)用(yong)的基質有水(shui)(shui)溶(rong)性(xing)和非(fei)水(shui)(shui)溶(rong)性(xing)兩類，水(shui)(shui)溶(rong)性(xing)基質常(chang)(chang)選(xuan)擇聚(ju)乙二醇類、硬脂酸鈉(na)及(ji)甘油明(ming)膠等(deng)(deng)(deng)，非(fei)水(shui)(shui)溶(rong)性(xing)基質常(chang)(chang)選(xuan)擇硬脂酸及(ji)蟲蠟等(deng)(deng)(deng)。常(chang)(chang)用(yong)的冷凝液(ye)有水(shui)(shui)或不同濃度(du)的乙醇溶(rong)液(ye)及(ji)液(ye)體石蠟、植物油等(deng)(deng)(deng)。目前滴(di)(di)丸(wan)(wan)(wan)劑的制法可分為(wei)下(xia)行滴(di)(di)法（懸(xuan)滴(di)(di)）、上行滴(di)(di)法（躺滴(di)(di)）、定量(liang)制丸(wan)(wan)(wan)法等(deng)(deng)(deng)幾(ji)種。滴(di)(di)制法的一(yi)般工藝流程(cheng)為(wei)：藥(yao)物+基質→混懸(xuan)、乳化、溶(rong)融→滴(di)(di)制→冷卻→洗丸(wan)(wan)(wan)→干燥→選(xuan)丸(wan)(wan)(wan)→質檢→分裝。

隨著生活水平(ping)的(de)(de)(de)(de)不斷提高，各(ge)種心血管(guan)(guan)疾病(bing)越(yue)來越(yue)多(duo)地困擾(rao)著人(ren)們。滴(di)(di)(di)丸(wan)(wan)(wan)在心血管(guan)(guan)疾病(bing)的(de)(de)(de)(de)治療(liao)方面有著舉足輕重的(de)(de)(de)(de)作用。從米內(nei)網中(zhong)成藥(yao)相關數據來看(kan)，滴(di)(di)(di)丸(wan)(wan)(wan)在心腦血管(guan)(guan)、五官、呼吸及消化(hua)系統(tong)等疾病(bing)中(zhong)應用較廣。但從目前(qian)我國的(de)(de)(de)(de)中(zhong)藥(yao)滴(di)(di)(di)丸(wan)(wan)(wan)劑(ji)(ji)的(de)(de)(de)(de)現(xian)狀來看(kan)，國內(nei)藥(yao)用高分子材料(liao)發(fa)展的(de)(de)(de)(de)相對滯后，導(dao)(dao)致(zhi)可供選擇的(de)(de)(de)(de)基質和冷凝劑(ji)(ji)較少；藥(yao)物精制(zhi)純化(hua)水平(ping)低下，導(dao)(dao)致(zhi)適(shi)合制(zhi)成滴(di)(di)(di)丸(wan)(wan)(wan)的(de)(de)(de)(de)品種不多(duo)；滴(di)(di)(di)丸(wan)(wan)(wan)機制(zhi)造商(shang)與滴(di)(di)(di)丸(wan)(wan)(wan)開發(fa)的(de)(de)(de)(de)企業分離(li)，導(dao)(dao)致(zhi)設備水平(ping)遠(yuan)遠(yuan)落后于滴(di)(di)(di)丸(wan)(wan)(wan)技(ji)術(shu)的(de)(de)(de)(de)發(fa)展。因此作為(wei)中(zhong)成藥(yao)制(zhi)劑(ji)(ji)的(de)(de)(de)(de)現(xian)代劑(ji)(ji)型，滴(di)(di)(di)丸(wan)(wan)(wan)在市場銷售份額中(zhong)遠(yuan)沒(mei)有片劑(ji)(ji)、膠囊及注(zhu)射劑(ji)(ji)風(feng)光，但隨著制(zhi)劑(ji)(ji)工藝的(de)(de)(de)(de)逐步(bu)完善(shan)，中(zhong)藥(yao)滴(di)(di)(di)丸(wan)(wan)(wan)劑(ji)(ji)必將(jiang)擁有更廣闊的(de)(de)(de)(de)前(qian)景，為(wei)中(zhong)藥(yao)現(xian)代化(hua)帶來新的(de)(de)(de)(de)活力(li)。

根(gen)據米內網-中(zhong)成(cheng)藥(yao)臨(lin)床(chuang)終端競(jing)爭格(ge)局顯示，近幾(ji)年來在(zai)心腦血管、五(wu)官等方面應(ying)用的(de)中(zhong)藥(yao)滴丸類品種的(de)*雖不占據位置(zhi)(zhi)，但(dan)在(zai)某(mou)些亞(ya)類位置(zhi)(zhi)居(ju)前。在(zai)滴丸這個劑型的(de)銷(xiao)售市場來看，某(mou)些品種由(you)于市場接受(shou)度高，始(shi)終占據銷(xiao)售排行的(de)位置(zhi)(zhi)。

產品簡介
本機是通過設置旋轉離心盤、鼓風機、氣動噴槍，將濕顆粒制成美麗的球丸。將前道工序做成的濕顆粒投入旋轉離心盤內，啟動鼓風機后再將旋轉離心盤啟動，使濕顆粒受到環隙空氣浮力、旋轉離心力、自身重力作用，呈環周繩股狀運動，從而形成真球度高的球丸。
This machine makes damp granule into beautiful pellet by setting rotating centrifugal disk, blower, and pneumatic nozzle. Feed damp granule into rotating centrifugal disk, start fan then start rotating centrifugal disk. It can make the damp granule undertaken the action of air floating force in ring gap, rotating centrifugal strength and gravity itself, appear circle rope-turning movement and become high-degree ball shape pellet.